GIT2 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		GIT2	ARHGEF6
Description		GIT ArfGAP 2	Rac/Cdc42 guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Cytosol Lamellipodium
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Catalytic Activity	Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity
Pathways		CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)	Breast cancer ( 29059683)
Interacting Genes		48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		9815	9459
HPRD ID		09779	02226
Ensembl ID		ENSG00000139436	ENSG00000129675
Uniprot IDs		F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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