ARHGEF6 and TMEM108

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		ARHGEF6	TMEM108
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	transmembrane protein 108
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Lamellipodium	Cellular_component Early Endosome Endosome Membrane Postsynaptic Density Integral Component Of Membrane Axon Dendrite Somatodendritic Compartment Axon Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Molecular_function Protein Binding
	Biological Process	Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity	Receptor-mediated Endocytosis Retrograde Axonal Transport Biological_process Dentate Gyrus Development Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Density Organization Dendrite Extension Modulation Of Excitatory Postsynaptic Potential Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Bipolar disorder ( 33263727) Chronotype ( 30696823) Daytime nap ( 33568662) IgE grass sensitization ( 22036096) Iron status biomarkers (total iron binding capacity) ( 28334935) Menarche (age at onset) ( 27182965 21102462) Parkinson's disease progression (cognitive) ( 33958783) Stroke ( 32693751) Systolic blood pressure ( 30224653 30578418) Waist circumference ( 28552196)
Interacting Genes		38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	7 interacting genes: ANXA7 ARHGEF6 FHL3 FKBP7 NOTCH3 SGTB SH3GL2
Entrez ID		9459	66000
HPRD ID		02226	11329
Ensembl ID		ENSG00000129675	ENSG00000144868
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	B3KT64 Q6UXF1
PDB IDs		1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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