SOCS5 and IL4R

Number of citations of the paper that reports this interaction (PubMedID 12242343)
57

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		SOCS5	IL4R
Description		suppressor of cytokine signaling 5	interleukin 4 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Interleukin-4 Receptor Activity Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of Inflammatory Response Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Monocyte Chemotactic Protein-1 Production Vascular Endothelial Cell Response To Fluid Shear Stress	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant
Pathways		Interleukin-4 and Interleukin-13 signaling Neddylation	Interleukin-4 and Interleukin-13 signaling
Drugs			AER001 Dupilumab
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Current cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Height ( 28552196 20881960) Offspring birth weight ( 31043758) Pulse pressure (alcohol consumption interaction) ( 24376456) Waist circumference adjusted for body mass index ( 34021172)	Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		12 interacting genes: APP CASP3 EGFR ERBB2 ERBB3 ERBB4 IL4R KIT MET PLCB2 TMBIM1 UBC	28 interacting genes: ARIH2 CD40 DOK2 ERN2 FES HDGFL3 HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 NPIPB5 PRKCZ PTPN11 PTPN6 RACK1 RBBP6 SHC1 SLC20A1 SOCS5 STAT6
Entrez ID		9655	3566
HPRD ID		06159	00990
Ensembl ID		ENSG00000171150	ENSG00000077238
Uniprot IDs		O75159	B2RBY1 P24394
PDB IDs			1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL
Enriched GO Terms of Interacting Partners?
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