IL4R and STAT6

Number of citations of the paper that reports this interaction (PubMedID 9392697)
116

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro)

		IL4R	STAT6
Description		interleukin 4 receptor	signal transducer and activator of transcription 6
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Chromatin Nucleoplasm Cytosol Membrane Raft
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Reactive Nitrogen Species
Pathways		Interleukin-4 and Interleukin-13 signaling	Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling
Drugs		AER001 Dupilumab
Diseases
GWAS		Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)	Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		28 interacting genes: ARIH2 CD40 DOK2 ERN2 FES HDGFL3 HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 NPIPB5 PRKCZ PTPN11 PTPN6 RACK1 RBBP6 SHC1 SLC20A1 SOCS5 STAT6	39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PPARG PRIM1 PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		3566	6778
HPRD ID		00990	03302
Ensembl ID		ENSG00000077238	ENSG00000166888
Uniprot IDs		B2RBY1 P24394	A8K4S9 B4DQB3 H0YJH6 P42226
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL	1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX
Enriched GO Terms of Interacting Partners?
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