IL4R and HDGFL3

		IL4R	HDGFL3
Description		interleukin 4 receptor	HDGF like 3
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GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Extracellular Region Nucleus Nucleoplasm Cytosol
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Double-stranded DNA Binding Transcription Coregulator Activity Microtubule Binding Growth Factor Activity Tubulin Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Microtubule Depolymerization Signal Transduction Neuron Projection Development Microtubule Polymerization
Pathways		Interleukin-4 and Interleukin-13 signaling
Drugs		AER001 Dupilumab
Diseases
GWAS		Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		28 interacting genes: ARIH2 CD40 DOK2 ERN2 FES HDGFL3 HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 NPIPB5 PRKCZ PTPN11 PTPN6 RACK1 RBBP6 SHC1 SLC20A1 SOCS5 STAT6	6 interacting genes: ADAMTSL3 H3C1 IL4R SMURF1 SMURF2 TERF2IP
Entrez ID		3566	50810
HPRD ID		00990	17096
Ensembl ID		ENSG00000077238	ENSG00000166503
Uniprot IDs		B2RBY1 P24394	A0A024R216 Q9Y3E1
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL	6IIP 6IIQ 6IIR 6IIS 6IIT
Enriched GO Terms of Interacting Partners?
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