IL4R and DOK2

Number of citations of the paper that reports this interaction (PubMedID 10856136)
94

Data Source:
HPRD (in vitro)

		IL4R	DOK2
Description		interleukin 4 receptor	docking protein 2
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Centriolar Satellite Receptor Complex	Cytoplasm Cytosol
	Molecular Function	Interleukin-4 Receptor Activity Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Immunoglobulin Production Immune Response Signal Transduction Immunoglobulin Mediated Immune Response Ovulation Positive Regulation Of Chemokine Production Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Defense Response To Protozoan Positive Regulation Of Macrophage Activation Positive Regulation Of Mast Cell Degranulation Response To Estrogen Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Myoblast Fusion Response To Odorant	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways		Interleukin-4 and Interleukin-13 signaling	Tie2 Signaling RET signaling
Drugs		AER001 Dupilumab
Diseases
GWAS		Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (time to onset) ( 27130862) Asthma onset (childhood vs adult) ( 30929738) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494 27863252) IgE levels ( 22075330) Leprosy ( 27976721) Medication use (adrenergics, inhalants) ( 31015401) Night sleep phenotypes ( 27126917) Primary biliary cholangitis ( 28425483 26394269) Self-reported allergy ( 23817569) Serum IgE levels ( 25488688) Sum eosinophil basophil counts ( 27863252)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Entorhinal cortical thickness ( 21116278) Lymphocyte counts ( 32888494) Mean corpuscular volume ( 20139978) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neuropathic pain in type 2 diabetes ( 24974787) Neutrophil percentage of white cells ( 32888494) Pancreatic cancer ( 30206226) Platelet distribution width ( 32888494) Refractive error ( 32231278) Verbal declarative memory ( 25648963)
Interacting Genes		28 interacting genes: ARIH2 CD40 DOK2 ERN2 FES HDGFL3 HGS IL13 IL13RA1 IL13RA2 IL2RG IL4 INPP5D IRS1 IRS2 JAK1 JAK2 JAK3 NPIPB5 PRKCZ PTPN11 PTPN6 RACK1 RBBP6 SHC1 SLC20A1 SOCS5 STAT6	22 interacting genes: ABL1 APPL1 CRK CRKL CSK DOK3 EGFR HCK IL4R INPP5D KIFBP LCK LYN NCK1 POT1 RASA1 RET SRC STAT3 TEK TXK YES1
Entrez ID		3566	9046
HPRD ID		00990	05411
Ensembl ID		ENSG00000077238	ENSG00000147443
Uniprot IDs		B2RBY1 P24394	B4DKQ6 O60496
PDB IDs		1IAR 1IRS 1ITE 3BPL 3BPN 3BPO 5E4E 6OEL 6WGL	2D9W 2DLW
Enriched GO Terms of Interacting Partners?
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