RUNX3 and TNFRSF8

		RUNX3	TNFRSF8
Description		RUNX family transcription factor 3	TNF receptor superfamily member 8
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Core-binding Factor Complex Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding	Transmembrane Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hemopoiesis Neuron Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Response To Transforming Growth Factor Beta	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription	TNFs bind their physiological receptors
Drugs			XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Ankylosing spondylitis ( 23749187 21743469) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Celiac disease ( 22057235 20190752) Crohn's disease ( 23266558) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) IgA levels ( 28628107) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels ( 26025379) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Type 1 diabetes ( 34012112)	Asthma ( 31959851 34103634 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		19 interacting genes: CBFB EP300 GLI1 GUCD1 HDAC1 HDAC2 HDAC4 HDAC5 HPCA MYCN NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 TNFRSF8 TP53 YAP1	14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73
Entrez ID		864	943
HPRD ID		02565	01074
Ensembl ID		ENSG00000020633	ENSG00000120949
Uniprot IDs		A0A024RAH4 Q13761	A5D8T4 P28908
PDB IDs		5W69	1D01
Enriched GO Terms of Interacting Partners?
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