TNFRSF8 and TDP2

Number of citations of the paper that reports this interaction (PubMedID 10764746)
47

Data Source:
HPRD (two hybrid, in vivo)

		TNFRSF8	TDP2
Description		TNF receptor superfamily member 8	tyrosyl-DNA phosphodiesterase 2
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Aggresome Nuclear Body PML Body
	Molecular Function	Transmembrane Signaling Receptor Activity	Magnesium Ion Binding Single-stranded DNA Binding Transcription Corepressor Activity Nuclease Activity Protein Binding Manganese Ion Binding Tyrosyl-RNA Phosphodiesterase Activity 5'-tyrosyl-DNA Phosphodiesterase Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus	Double-strand Break Repair Cell Surface Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Neuron Development Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		TNFs bind their physiological receptors	Nonhomologous End-Joining (NHEJ)
Drugs		XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Asthma ( 31959851 34103634 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)	Colorectal or endometrial cancer ( 26621817)
Interacting Genes		14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73	37 interacting genes: AKAP9 ATP5MC2 ATXN1 BLK BTBD2 C2orf88 CD40 DLX3 DVL2 EPS8 ETS1 ETS2 FLI1 GOLGA2 JAM2 MAPK6 NOTCH4 PSEN1 RAB11A SKIL SMAD3 SNX13 SRPK2 SUMO1 SUMO2 SUMO3 TAP1 TFIP11 TNFRSF1B TNFRSF8 TRAF2 TRAF3 TRAF5 TRAF6 UBE2I WBP2 ZBED1
Entrez ID		943	51567
HPRD ID		01074	05771
Ensembl ID		ENSG00000120949	ENSG00000111802
Uniprot IDs		A5D8T4 P28908	A0A384MDM5 O95551
PDB IDs		1D01	5INO 5J3P 5J3S 6Q00 6Q01
Enriched GO Terms of Interacting Partners?
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