TNFRSF8 and CLCN6

		TNFRSF8	CLCN6
Description		TNF receptor superfamily member 8	chloride voltage-gated channel 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Lysosomal Membrane Endosome Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Transmembrane Signaling Receptor Activity	Voltage-gated Chloride Channel Activity ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus	Chloride Transport Cell Volume Homeostasis Signal Transduction Response To Mechanical Stimulus Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		TNFs bind their physiological receptors	Stimuli-sensing channels Signaling by BRAF and RAF1 fusions
Drugs		XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Asthma ( 31959851 34103634 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)	Arterial stiffness index ( 31235810) Coronary artery disease ( 29212778) Diastolic blood pressure ( 29615537) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Natriuretic peptide levels ( 21273288) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Red cell distribution width ( 32888494) Systolic blood pressure ( 19430483 29615537 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Testicular germ cell tumor ( 28604728) Tuberculosis ( 29036319)
Interacting Genes		14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73	2 interacting genes: ERBB2 TNFRSF8
Entrez ID		943	1185
HPRD ID		01074	04102
Ensembl ID		ENSG00000120949	ENSG00000011021
Uniprot IDs		A5D8T4 P28908	P51797
PDB IDs		1D01
Enriched GO Terms of Interacting Partners?
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