TNFRSF8 and SH3BGRL3

		TNFRSF8	SH3BGRL3
Description		TNF receptor superfamily member 8	SH3 domain binding glutamate rich protein like 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Cytoplasm Nuclear Body Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity	Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of TRAIL Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Cellular Response To Mechanical Stimulus
Pathways		TNFs bind their physiological receptors
Drugs		XmAb 2513 Brentuximab vedotin
Diseases
GWAS		Asthma ( 31959851 34103634 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Serum alkaline phosphatase levels ( 33339817) Sum eosinophil basophil counts ( 27863252) Tuberculosis ( 29036319)
Interacting Genes		14 interacting genes: ALK CLCN6 EPHA2 HPCA PRDX4 RUNX3 SH3BGRL3 TDP2 TNFSF8 TRAF1 TRAF2 TRAF3 TRAF5 WRAP73	6 interacting genes: APP CDC42 DDIT4L EGFR ERBB2 TNFRSF8
Entrez ID		943	83442
HPRD ID		01074	15332
Ensembl ID		ENSG00000120949	ENSG00000142669
Uniprot IDs		A5D8T4 P28908	Q9H299
PDB IDs		1D01	1SJ6
Enriched GO Terms of Interacting Partners?
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