RUNX3 and SP110

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		RUNX3	SP110
Description		RUNX family transcription factor 3	SP110 nuclear body protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Core-binding Factor Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hemopoiesis Neuron Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Response To Transforming Growth Factor Beta	Regulation Of Transcription By RNA Polymerase II
Pathways		Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Ankylosing spondylitis ( 23749187 21743469) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Celiac disease ( 22057235 20190752) Crohn's disease ( 23266558) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) IgA levels ( 28628107) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels ( 26025379) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Type 1 diabetes ( 34012112)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Chronic lymphocytic leukemia ( 18758461 28165464 24292274) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		19 interacting genes: CBFB EP300 GLI1 GUCD1 HDAC1 HDAC2 HDAC4 HDAC5 HPCA MYCN NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 TNFRSF8 TP53 YAP1	12 interacting genes: AGAP1 ANXA7 CDKN1A NAP1L2 NDUFV2 OSGEP RUNX3 SMN1 TK1 TSC22D1 TTR ZSCAN9
Entrez ID		864	3431
HPRD ID		02565	06832
Ensembl ID		ENSG00000020633	ENSG00000135899
Uniprot IDs		A0A024RAH4 Q13761	Q9HB58
PDB IDs		5W69
Enriched GO Terms of Interacting Partners?
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