SPOP and LRCH4

Number of citations of the paper that reports this interaction (PubMedID 28805822)
78

Data Source:
BioGRID (two hybrid)

		SPOP	LRCH4
Description		speckle type BTB/POZ protein	leucine rich repeats and calponin homology domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	PML Body
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Nervous System Development
Pathways		Hedgehog 'on' state
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	17 interacting genes: CA8 CYB5R3 ELOVL7 HSD17B11 KASH5 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NLA PRKAR2B RBBP6 RETREG3 RNASEK RTN4 SIN3A SPOP
Entrez ID		8405	4034
HPRD ID		16004	10062
Ensembl ID		ENSG00000121067	ENSG00000077454
Uniprot IDs		O43791	O75427
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D
Enriched GO Terms of Interacting Partners?
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