SPOP and GCC2

Number of citations of the paper that reports this interaction (PubMedID 28805822)
78

Data Source:
BioGRID (two hybrid)

		SPOP	GCC2
Description		speckle type BTB/POZ protein	GRIP and coiled-coil domain containing 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleoplasm Golgi Apparatus Trans-Golgi Network Cytosol Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Small GTPase Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Targeting To Lysosome Microtubule Organizing Center Organization Protein Localization To Golgi Apparatus Microtubule Anchoring Late Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Golgi To Plasma Membrane Protein Transport Regulation Of Protein Exit From Endoplasmic Reticulum Recycling Endosome To Golgi Transport Golgi Ribbon Formation
Pathways		Hedgehog 'on' state	Retrograde transport at the Trans-Golgi-Network Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Mean platelet volume ( 27863252) Platelet distribution width ( 32888494)
Interacting Genes		68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	7 interacting genes: ARL1 ICAM3 POU2AF1 RANBP2 SPOP SRPK2 SULT1C3
Entrez ID		8405	9648
HPRD ID		16004	11001
Ensembl ID		ENSG00000121067	ENSG00000135968
Uniprot IDs		O43791	B3KR21 Q8IWJ2
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D	3BBP
Enriched GO Terms of Interacting Partners?
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