LRCH4 and HSD17B11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LRCH4	HSD17B11
Description		leucine rich repeats and calponin homology domain containing 4	hydroxysteroid 17-beta dehydrogenase 11
Image		No pdb structure
GO Annotations	Cellular Component	PML Body	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity
	Biological Process	Nervous System Development	Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways			Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Macular thickness ( 30535121) Subcortical volume (MOSTest) ( 32665545)	Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		17 interacting genes: CA8 CYB5R3 ELOVL7 HSD17B11 KASH5 KRT40 KRTAP10-7 KRTAP10-8 MDFI NOTCH2NLA PRKAR2B RBBP6 RETREG3 RNASEK RTN4 SIN3A SPOP	54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC22A18 SLC25A46 SLC30A8 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6
Entrez ID		4034	51170
HPRD ID		10062	10881
Ensembl ID		ENSG00000077454	ENSG00000198189
Uniprot IDs		O75427	Q8NBQ5
PDB IDs			1YB1
Enriched GO Terms of Interacting Partners?
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