SMC1A and ALK

		SMC1A	ALK
Description		structural maintenance of chromosomes 1A	ALK receptor tyrosine kinase
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Mitotic Spindle Pole	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Phosphorylation Peptidyl-tyrosine Phosphorylation Hippocampus Development Adult Behavior Positive Regulation Of Kinase Activity Swimming Behavior NIK/NF-kappaB Signaling Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026- resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer
Drugs			ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)	Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)
Interacting Genes		21 interacting genes: ALK AMOT ATM BLM BRCA1 ESR1 FGF14 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2	28 interacting genes: BIRC6 CLNS1A DLG2 DNMT3A DUSP19 ERBB2 HADHB HMGB1 IKBKG IRS1 JAK3 MDK MSH2 NLRC4 NPM1 PIK3R1 PLCG1 PPM1A PTN PTPRZ1 RASA1 SHC1 SHC3 SMC1A TNFRSF8 TSPAN16 TTC19 ZC3HC1
Entrez ID		8243	238
HPRD ID		02077	00104
Ensembl ID		ENSG00000072501	ENSG00000171094
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	B6D4Y2 Q9UM73
PDB IDs		6WG3 6WG4 6WG6 6WGE	2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7JY4 7JYR 7JYS 7JYT
Enriched GO Terms of Interacting Partners?
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