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SMC1A

Description structural maintenance of chromosomes 1A
Image
GO Annotations Cellular Component
  • Chromosome, Centromeric Region
  • Kinetochore
  • Condensed Nuclear Chromosome
  • Nucleus
  • Nucleoplasm
  • Chromosome
  • Cytosol
  • Cohesin Complex
  • Nuclear Matrix
  • Meiotic Cohesin Complex
  • Mitotic Spindle Pole
Molecular Function
  • DNA Binding
  • Chromatin Binding
  • RNA Binding
  • Protein Binding
  • ATP Binding
  • Mediator Complex Binding
  • Protein Heterodimerization Activity
Biological Process
  • Mitotic Sister Chromatid Segregation
  • DNA Repair
  • Sister Chromatid Cohesion
  • Mitotic Sister Chromatid Cohesion
  • Response To Radiation
  • Stem Cell Population Maintenance
  • Cell Division
  • Meiotic Cell Cycle
  • Response To DNA Damage Checkpoint Signaling
  • Mitotic Spindle Assembly
Pathways
  • Meiotic synapsis
  • Separation of Sister Chromatids
  • Establishment of Sister Chromatid Cohesion
  • Cohesin Loading onto Chromatin
  • Resolution of Sister Chromatid Cohesion
  • SUMOylation of DNA damage response and repair proteins
  • Estrogen-dependent gene expression
Drugs
Diseases
GWAS
  • Bipolar disorder ( 31043756)
  • Mean corpuscular volume ( 32888494)
Interacting Genes 21 interacting genes: ALK AMOT ATM BLM BRCA1 ESR1 FGF14 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2
Entrez ID 8243
HPRD ID 02077
Ensembl ID ENSG00000072501
Uniprot IDs A0A384MR33 G8JLG1 Q14683 Q68EN4
PDB IDs 6WG3 6WG4 6WG6 6WGE
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025