ALK and SHC1

Number of citations of the paper that reports this interaction (PubMedID 9174053)
127

Data Source:
HPRD (in vivo)

		ALK	SHC1
Description		ALK receptor tyrosine kinase	SHC adaptor protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Extracellular Exosome	Mitochondrial Matrix Cytosol Plasma Membrane Shc-EGFR Complex
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Phosphotyrosine Residue Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Insulin-like Growth Factor Receptor Binding Neurotrophin TRKA Receptor Binding Protein Binding Phospholipid Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Ephrin Receptor Binding Epidermal Growth Factor Binding
	Biological Process	Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Phosphorylation Peptidyl-tyrosine Phosphorylation Hippocampus Development Adult Behavior Positive Regulation Of Kinase Activity Swimming Behavior NIK/NF-kappaB Signaling Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of Neuron Differentiation Protein Autophosphorylation Neuron Development Negative Regulation Of Lipid Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Dopamine Receptor Signaling Pathway Response To Environmental Enrichment Energy Homeostasis Positive Regulation Of Dendrite Development	Angiogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Heart Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Actin Cytoskeleton Reorganization Intracellular Signal Transduction Regulation Of Growth Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cell-cell Adhesion
Pathways		Signaling by ALK Signaling by ALK ALK mutants bind TKIs ASP-3026- resistant ALK mutants NVP-TAE684-resistant ALK mutants alectinib resistant ALK mutants brigatinib-resistant ALK mutants ceritinib-resistant ALK mutants crizotinib-resistant ALK mutants lorlatinib-resistant ALK mutants Signaling by ALK fusions and activated point mutants Nuclear events stimulated by ALK signaling in cancer	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF)
Drugs		ATP Crizotinib Ceritinib Alectinib Fostamatinib Lorlatinib Gilteritinib Brigatinib
Diseases
GWAS		Adiponectin levels (BMI-adjusted) ( 26299439) Body mass index ( 25673413) Body size at age 10 ( 32376654) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Carbamazepine-induced serious cutaneous adverse reaction ( 31066027) Dentures ( 31235808) Gestational age at birth (child effect) ( 31194736) Glucose homeostasis traits ( 25524916) Low density lipoprotein cholesterol levels ( 33339817) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Pre-treatment viral load in HIV-1 infection ( 31219150) Simvastatin-induced myopathy ( 31220337) Spontaneous coronary artery dissection ( 32887874) Systolic blood pressure ( 26969751) Total cholesterol levels ( 33339817)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Eosinophil counts ( 29403010) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		28 interacting genes: BIRC6 CLNS1A DLG2 DNMT3A DUSP19 ERBB2 HADHB HMGB1 IKBKG IRS1 JAK3 MDK MSH2 NLRC4 NPM1 PIK3R1 PLCG1 PPM1A PTN PTPRZ1 RASA1 SHC1 SHC3 SMC1A TNFRSF8 TSPAN16 TTC19 ZC3HC1	146 interacting genes: ALK AP2A1 AP2A2 APP AR AXL BCL3 BCR BUB1 C11orf58 CALCOCO2 CALD1 CBL CBLB CBLC CD22 CD247 CD3E CD81 CDH5 CEACAM1 CRK CRKL CSF1R CSF2RB CSF3R CSK DAG1 DDR1 DDR2 DNAH7 DOK1 DUSP23 EGFR EPHA2 EPOR EPS8 ERBB2 ERBB3 ERBB4 ESR1 FAM118B FBXW7 FCGR2A FCGR3A FGFR1 FGFR2 FLT1 FLT3 FLT4 FYN GAB1 GAB2 GEMIN7 GH1 GHR GRAP GRAP2 GRB2 GRB7 HMOX2 IGF1R IL2 IL2RB IL2RG IL4R IL6ST ILK INPP5D INPPL1 INSR IRS1 IRS2 ITGB3 ITGB4 JAK2 KDR KIT KRT18 LCK LCP2 LRP1 LTK LYN MAP4K1 MAPK1 MAPK14 MAPK6 MAPK8 MAPKAPK2 MET MME MPL MRPL44 MST1R NGFR NPM1 NTRK1 NTRK2 NTRK3 NUDT21 OSGEP PAG1 PAK1 PDGFRB PIK3C2B PIK3R1 PIK3R2 PLCG1 PLCG2 PLPP3 PLSCR1 PPP2R5A PRKCA PRKCD PRKRA PTK2 PTK2B PTPN11 PTPN12 PTPN2 PTPN6 RAPGEF1 RASA1 RB1 RET SH2B2 SHCBP1 SMAD4 SOS1 SOS2 SP1 SRC STAT5A STAT5B SUV39H2 SYK TEC TEK TH TPR TRIM15 UBASH3B VAV1 VAV3 ZAP70
Entrez ID		238	6464
HPRD ID		00104	02780
Ensembl ID		ENSG00000171094	ENSG00000160691
Uniprot IDs		B6D4Y2 Q9UM73	P29353
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4CCB 4CCU 4CD0 4CLI 4CLJ 4CMO 4CMT 4CMU 4CNH 4CTB 4CTC 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA 4MKC 4TT7 4Z55 5A9U 5AA8 5AA9 5AAA 5AAB 5AAC 5FTO 5FTQ 5IMX 5IUG 5IUH 5IUI 5KZ0 5VZ5 6AT9 6CDT 6E0R 6EBW 6EDL 6MX8 7JY4 7JYR 7JYS 7JYT	1MIL 1N3H 1OY2 1QG1 1SHC 1TCE 1WCP 2L1C 4JMH 4XWX 5CZI 6DM4
Enriched GO Terms of Interacting Partners?
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