SMC1A and MDC1

Number of citations of the paper that reports this interaction (PubMedID 12607005)
332

Data Source:
HPRD (in vivo)

		SMC1A	MDC1
Description		structural maintenance of chromosomes 1A	mediator of DNA damage checkpoint 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Nuclear Chromosome Nucleus Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Mitotic Spindle Pole	Nucleus Nucleoplasm Chromosome Focal Adhesion Nuclear Body
	Molecular Function	DNA Binding Chromatin Binding RNA Binding Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity	Protein Binding Protein C-terminus Binding FHA Domain Binding
	Biological Process	Mitotic Sister Chromatid Segregation DNA Repair Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Response To Radiation Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Response To DNA Damage Checkpoint Signaling Mitotic Spindle Assembly	DNA Repair Mitotic Intra-S DNA Damage Checkpoint Signaling
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Mean corpuscular volume ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Eosinophil counts ( 31272903)
Interacting Genes		21 interacting genes: ALK AMOT ATM BLM BRCA1 ESR1 FGF14 MCM6 MCM7 MDC1 MET MSH2 MSH6 NDC80 NUMA1 POLA1 RAD21 RFC1 RPGR SMC3 SUMO2	41 interacting genes: ANAPC1 ATM BARD1 BDKRB1 BRCA1 CASP3 CENPC CHEK2 COPS5 CREBBP CSNK2A1 DTX2 EP300 GATA4 H2AX HDAC10 HDAC8 HINFP NBN NCL NSD2 PIAS1 PIAS4 PRIM1 PTEN RAD50 RAD51 RNF8 SMC1A SRPK2 SUMO2 TNKS2 TP53 TP53BP1 UIMC1 USP13 USP15 USP28 VAMP5 WRN ZNF251
Entrez ID		8243	9656
HPRD ID		02077	16252
Ensembl ID		ENSG00000072501	ENSG00000137337
Uniprot IDs		A0A384MR33 G8JLG1 Q14683 Q68EN4	A0A1U9XBC1 A1Z5I9 Q14676
PDB IDs		6WG3 6WG4 6WG6 6WGE	2ADO 2AZM 2ETX 3K05 3UEO 3UMZ 3UN0 3UNM 3UNN 3UOT
Enriched GO Terms of Interacting Partners?
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