MED25 and USP54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		MED25	USP54
Description		mediator complex subunit 25	ubiquitin specific peptidase 54
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Transcription Regulator Complex Mediator Complex
	Molecular Function	Transcription Coactivator Binding Protein Binding Transcription Factor Binding Retinoic Acid Receptor Binding Retinoid X Receptor Binding	Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Chromatin Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Regulation Of Cell Cycle Positive Regulation Of Mediator Complex Assembly	Protein Deubiquitination
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494)	Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		37 interacting genes: CDK8 CREBBP CTDP1 CYSRT1 ESRP1 EYA2 FAM168B HCFC1 HGS KLHL12 KRTAP6-1 KRTAP6-3 LASP1 MED1 MED15 MED6 MED8 MED9 NCKIPSD NR3C1 ODAM OXER1 PEF1 PLEKHB2 RARA RORB RUSC1 RXRA SERTAD3 SREBF1 STAT5B TFG THRA TLE5 USP54 WWOX WWP2	100 interacting genes: ANKRD11 ANKS1A ARID5B ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CDK19 CFAP70 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 CSTF2 CYSRT1 DMRT3 DOK6 DTX2 EIF4E2 EPM2AIP1 EXOC8 FAM124B FAM149B1 FBXO17 FNDC3B FOXI1 FUT11 GCM2 HGS HK1 HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 MSS51 MSX2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLCD1 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SAMD8 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 TTYH1 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76
Entrez ID		81857	159195
HPRD ID		14380	15641
Ensembl ID		ENSG00000104973	ENSG00000166348
Uniprot IDs		Q71SY5	B7Z7X1 Q70EL1
PDB IDs		2KY6 2L23 2L6U 2XNF
Enriched GO Terms of Interacting Partners?
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