USP54 and MSX2

		USP54	MSX2
Description		ubiquitin specific peptidase 54	msh homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Cytosol Nuclear Speck
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Cardiac Conduction System Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Embryonic Morphogenesis Cranial Suture Morphogenesis Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of RUNX2 expression and activity
Drugs
Diseases
GWAS		Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer's disease ( 33074286) Blond vs. brown/black hair color ( 30531825) Chin dimples ( 27182965) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Red vs. brown/black hair color ( 30531825) Resistant hypertension ( 30237584) Stroke ( 26089329)
Interacting Genes		100 interacting genes: ANKRD11 ANKS1A ARID5B ARMC7 ATN1 ATXN1 ATXN1L ATXN7L2 BFSP2 BHLHE40 CARD10 CCDC13 CCDC24 CCNK CDC23 CDK19 CFAP70 CHCHD2 CHERP CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 CSTF2 CYSRT1 DMRT3 DOK6 DTX2 EIF4E2 EPM2AIP1 EXOC8 FAM124B FAM149B1 FBXO17 FNDC3B FOXI1 FUT11 GCM2 HGS HK1 HNF1B HNRNPF HOXC8 IGFN1 INSC KCTD9 LMO3 LNX1 MED25 MID2 MSS51 MSX2 NUDT22 NXT2 OIP5 OTX1 PCSK5 PHF1 PLA2G6 PLAC8 PLCD1 PLEKHN1 POLR1C PRDM6 PRKAB2 PRR35 QRICH1 RACK1 RAMAC RBPMS2 RHOBTB3 RNF208 SAMD8 SEC24A SHARPIN SHC3 SMARCD1 SMYD1 SNRPB SS18L1 STK16 TBX6 TCEA2 TEKT5 TENT5B TFAP2D TLE5 TNS2 TOLLIP TSEN15 TSSK3 TTC19 TTYH1 UBC USP2 VENTX ZCCHC14 ZNF148 ZNF76	56 interacting genes: ATXN1 CCDC102B CEBPA CLIC3 DLX2 DLX5 EPHB6 FBXW2 FOXH1 GATA2 GTF2F1 GTF2F2 HOXC9 LENG8 MAGED1 MAPK1 MAPK1IP1L MAT2B MGAT5B MSX1 NAF1 NR3C1 PATZ1 PIAS2 PITX1 POLR3D POU1F1 POU2AF1 POU2F2 POU6F2 PPARG PRR13 RBPMS2 RHOXF2 ROR2 RUNX2 SMAP2 SOX5 SPEN TCF7L2 TENT5D TLE1 TLE2 TLE5 TLX3 TOLLIP TSSK3 USP54 VEZF1 XRCC5 XRCC6 YTHDF1 ZBTB17 ZC3H10 ZDHHC2 ZFHX3
Entrez ID		159195	4488
HPRD ID		15641	00421
Ensembl ID		ENSG00000166348	ENSG00000120149
Uniprot IDs		B7Z7X1 Q70EL1	P35548
PDB IDs
Enriched GO Terms of Interacting Partners?
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