ZNF426 and CARD9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZNF426	CARD9
Description		zinc finger protein 426	caspase recruitment domain family member 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Cytosol Plasma Membrane CBM Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Protein Binding Protein Homodimerization Activity Protein Self-association Metal Ion Binding CARD Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Cytokine Production Neutrophil Mediated Immunity I-kappaB Kinase/NF-kappaB Signaling Response To Xenobiotic Stimulus Immunoglobulin Mediated Immune Response Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Host-mediated Regulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Antifungal Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of T-helper 17 Type Immune Response
Pathways		Generic Transcription Pathway	NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Takayasu arteritis ( 33308445) Ulcerative colitis ( 19915572 28067908 20228799 21297633)
Interacting Genes		45 interacting genes: ACTN3 ANKRD11 ARMC7 ATPAF2 BYSL CALCOCO2 CARD9 CCDC85B CCNC CDK18 CEP70 CIB3 CTNNA3 DUSP4 EFEMP2 ENKD1 FAM161A GLRX3 GSDMD HEXIM2 KCTD9 KRT3 KRTAP4-12 LNX1 LONRF1 LPXN LZTS2 MAGOHB MALSU1 MAP2K5 MDFI MPPE1 MTUS2 NATD1 NINL OPTN PARVG RFC5 RHOJ TEKT4 TSGA10 USP25 ZGPAT ZNF330 ZSCAN23	138 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CABP2 CARD10 CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DISC1 DUSP13 DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GAS8 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TEX33 TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3
Entrez ID		79088	64170
HPRD ID		15787	06236
Ensembl ID		ENSG00000130818	ENSG00000187796
Uniprot IDs		A0A024R7D7 K7EME3 K7ER43 Q59EH4 Q9BUY5	A0A024R8F1 Q9H257
PDB IDs			6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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