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CARD9 and USP15
Number of citations of the paper that reports this interaction (PubMedID
33093067
)
0
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
CARD9
USP15
Description
caspase recruitment domain family member 9
ubiquitin specific peptidase 15
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
CBM Complex
Protein-containing Complex
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Molecular Function
Protein Binding
Protein Homodimerization Activity
Protein Self-association
Metal Ion Binding
CARD Domain Binding
Cysteine-type Endopeptidase Activity
Thiol-dependent Deubiquitinase
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Modification-dependent Histone Binding
Lys48-specific Deubiquitinase Activity
Biological Process
Positive Regulation Of Cytokine Production
Neutrophil Mediated Immunity
I-kappaB Kinase/NF-kappaB Signaling
Response To Xenobiotic Stimulus
Immunoglobulin Mediated Immune Response
Response To Peptidoglycan
Response To Muramyl Dipeptide
Regulation Of Interleukin-2 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Exogenous DsRNA
Positive Regulation Of Innate Immune Response
Positive Regulation Of JNK Cascade
Host-mediated Regulation Of Intestinal Microbiota Composition
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homooligomerization
Defense Response To Virus
Antifungal Innate Immune Response
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of T-helper 17 Type Immune Response
Ubiquitin-dependent Protein Catabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Protein Deubiquitination
BMP Signaling Pathway
Monoubiquitinated Protein Deubiquitination
Histone H2B Conserved C-terminal Lysine Deubiquitination
Pathway-restricted SMAD Protein Phosphorylation
Protein K48-linked Deubiquitination
Positive Regulation Of RIG-I Signaling Pathway
Negative Regulation Of Antifungal Innate Immune Response
Protein K27-linked Deubiquitination
Pathways
NOD1/2 Signaling Pathway
CLEC7A (Dectin-1) signaling
Downregulation of TGF-beta receptor signaling
UCH proteinases
Ub-specific processing proteases
Drugs
Diseases
GWAS
Acute insulin response (insulin secretion adjusted) (
28490609
)
Ankylosing spondylitis (
23749187
21743469
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
22936669
21102463
)
Hip circumference adjusted for BMI (
34021172
)
IgA nephropathy (
25305756
)
Inflammatory bowel disease (
28067908
23128233
)
Joint damage in rheumatoid arthritis (
26498133
)
Large artery stroke (
28265093
)
Monocyte chemoattractant protein-1 levels (
23017229
)
Obesity-related traits (
23251661
)
Pediatric autoimmune diseases (
26301688
)
Takayasu arteritis (
33308445
)
Ulcerative colitis (
19915572
28067908
20228799
21297633
)
Alopecia areata (
25608926
)
Metabolite levels (
23823483
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Pulmonary function decline (
22424883
)
Pyoderma gangrenosum in inflammatory bowel disease (
24487271
)
Interacting Genes
138 interacting genes:
ABLIM1
AMOTL2
AXIN1
BCL10
BLZF1
C1orf94
C2CD6
CABP2
CARD10
CBX8
CCDC13
CCDC136
CCDC85B
CCDC88B
CCHCR1
CDC37
CDCA7L
CDK2AP1
CEP57L1
CEP70
CSNK2A1
CWF19L2
DAXX
DISC1
DUSP13
DVL2
EFHC2
EIF4A3
EIF4E2
FAM124B
FAM161A
FAM161B
FAM50B
FAM90A1
FOXD4L1
GAS8
GEM
HMBOX1
HOXB5
HSF2BP
IHO1
IKZF3
INO80B
IQCE
KANK2
KCTD9
KIAA0408
KIAA1328
KIF9
KIFC3
KRT15
KRT16
KRT19
KRT31
KRT40
KRT75
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP5-7
L3MBTL2
LENG1
LMO1
LMO3
LNX1
LZTS1
LZTS2
MCRS1
MEOX2
MFAP1
MID2
MYO15B
NECAB2
NTAQ1
PAK5
PBX2
PHC2
PIBF1
PICK1
PKP2
PNMA5
PPP1R18
PRPF18
PSMA4
RBAK
RTP5
SAXO1
SCNM1
SHISA6
SLAIN1
SSX2IP
STMN3
STX11
SUMO1
TASOR2
TCEANC
TCL1A
TEX33
TFIP11
TLE5
TNFAIP1
TNS4
TRIM14
TRIM23
TRIM29
TRIM42
TRIM54
TRIM62
TSGA10IP
TSNAX
UBE2I
UNKL
USH1G
USP15
USP2
VCPKMT
VPS28
YES1
ZBTB16
ZC2HC1C
ZCCHC7
ZGPAT
ZMYM5
ZNF121
ZNF19
ZNF20
ZNF250
ZNF417
ZNF426
ZNF572
ZNF587
ZNF620
ZNF655
ZNF688
ZNF774
ZNF829
ZRANB1
ZZZ3
55 interacting genes:
BAP1
BMI1
BMPR1A
BRAP
CARD9
CCDC57
CDK4
DDX58
FHL1
GEMIN4
GOLGA2
GOLGA6A
H2BC21
IL1R2
JOSD1
KEAP1
MAD1L1
MDC1
MDM2
OTUB1
PHF7
PIBF1
PLA2G2A
PRPF31
RBCK1
RNF126
RNF144B
SENP3
SENP8
SMURF2
SPDL1
STAM
STK33
SYVN1
TEX11
TRAF6
TRIM17
TRIM21
TRIM25
TRIM46
TRIM5
TRIM54
TRIM63
TRIM74
UCHL1
UCHL3
USP14
USP2
USP20
USP21
USP28
USP33
USP51
USP8
YOD1
Entrez ID
64170
9958
HPRD ID
06236
05293
Ensembl ID
ENSG00000187796
ENSG00000135655
Uniprot IDs
A0A024R8F1
Q9H257
Q9Y4E8
PDB IDs
6E25
6E26
6E27
6E28
6N2M
6N2P
1W6V
3LMN
3PPA
3PV1
3T9L
4A3O
4A3P
5JJW
6CPM
6CRN
6DJ9
6GH9
6GHA
6ML1
Enriched GO Terms of Interacting Partners
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