TSC1 and TANK

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TSC1	TANK
Description		TSC complex subunit 1	TRAF family member associated NFKB activator
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Actin Filament Plasma Membrane Cell Cortex Postsynaptic Density Membrane Lamellipodium Growth Cone Protein-containing Complex TSC1-TSC2 Complex Perinuclear Region Of Cytoplasm Chaperone Complex	Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Hsp70 Protein Binding GTPase Activating Protein Binding ATPase Inhibitor Activity Protein-containing Complex Binding Protein N-terminus Binding Chaperone Binding Hsp90 Protein Binding	Thiol-dependent Deubiquitinase Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding
	Biological Process	Kidney Development Neural Tube Closure Regulation Of Cell-matrix Adhesion Adaptive Immune Response RRNA Export From Nucleus Regulation Of Translation Potassium Ion Transport Cell-matrix Adhesion Negative Regulation Of Cell Population Proliferation Adult Locomotory Behavior Negative Regulation Of Neuron Projection Development Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Negative Regulation Of Translation Hippocampus Development Cerebral Cortex Development Cell Projection Organization Negative Regulation Of TOR Signaling Negative Regulation Of ATPase Activity Response To Insulin Negative Regulation Of GTPase Activity Myelination Memory T Cell Differentiation Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Cell Size Regulation Of Protein Kinase Activity Glucose Import Synapse Organization Protein Stabilization Regulation Of Stress Fiber Assembly Positive Regulation Of Stress Fiber Assembly Regulation Of Cell Cycle Positive Regulation Of Focal Adhesion Assembly Cardiac Muscle Cell Differentiation Activation Of GTPase Activity Cellular Response To Oxygen-glucose Deprivation Regulation Of Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Death	Proteolysis Cellular Response To DNA Damage Stimulus Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity
Pathways		Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs	TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Migraine without aura ( 23793025) Psoriasis ( 19169254)	Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)
Interacting Genes		179 interacting genes: ABI1 ACTN1 ACTN2 AKT1 ANKIB1 ANKRD24 ANKRD35 APPL2 AQP1 ARAF ARID5A ATN1 ATXN1 AURKA AXIN1 BAG3 BCL11A BECN1 BEND5 BRD3 C1orf94 CALCOCO2 CAPZA2 CASC3 CCDC120 CCDC88B CCL28 CCNB1 CCND2 CCNE1 CDK1 CDK4 CDK6 CDKN2A CDKN2B CDR2 CHCHD2 CNIH1 CNTRL CNTROB COG6 CSTF2 CTNNB1 DACH2 DCTN2 DMRT3 DOK5 EIF3A ENKD1 EZR FAM110A FAM222B FBF1 FCN1 FGFR4 FOLR2 FOXH1 FRS3 GCC1 GEMIN8 GFAP GLIS2 GOLGA2 GPANK1 GPATCH1 HECW1 HGS HNRNPM HOMER3 HOOK2 HOXC8 HR HSH2D ICA1 IGFN1 IKBKB KANSL2 KAT2A KAZN KDM1A KIF1C KIF5A KLC1 KLC4 LATS2 LENG1 LMO2 LRSAM1 LUC7L LZTS2 MAP2K5 MAPK14 MBIP MBP MSANTD3 MSN MT-ND1 MYC MYLIP MYOZ3 NDUFA9 NECAB2 NEFL NF2 NINL NKD2 NRBF2 PAEP PATL1 PATZ1 PHLDB1 PICK1 PITX1 PLK1 PLK2 POGZ POU6F2 PPFIA2 PPP1R18 PPP1R32 PRMT6 PTPA RALYL RASSF1 RBPMS RDX RHEB RIN1 RIN3 RUNDC3A SAMD11 SAMD7 SCMH1 SEC31A SELENOW SERTAD1 SH2D2A SHANK1 SHC3 SLC16A6 SMG9 SORBS3 SOX4 SPAG5 SPAG8 SUOX TANK TBC1D7 TBX6 TCF7L2 TFAP2D TFIP11 TLE5 TNS2 TRAF2 TRIM3 TRIOBP TSC2 TSGA10IP TSHZ3 TUBB4B VENTX VEZF1 VGLL3 VIM VPS37C YPEL3 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZIC1 ZNF417 ZNF423 ZNF587 ZNF765 ZNF79	33 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 LRP2 MAP4K5 MARCHF5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 TSC1 USP7 ZC3H12A
Entrez ID		7248	10010
HPRD ID		05594	04870
Ensembl ID		ENSG00000165699	ENSG00000136560
Uniprot IDs		A0A2R8Y5S3 Q32NF0 Q86WV8 Q92574 X5D9D2	B2R7S3 Q6NW12 Q92844
PDB IDs		4Z6Y 5EJC 7DL2	1KZZ 1L0A 5H10
Enriched GO Terms of Interacting Partners?
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