TANK and LAMC1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		TANK	LAMC1
Description		TRAF family member associated NFKB activator	laminin subunit gamma 1
Image
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Proteolysis Cellular Response To DNA Damage Stimulus Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly
Pathways		TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			Lanoteplase
Diseases
GWAS		Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) LDL cholesterol levels in HIV infection ( 33109212) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)
Interacting Genes		33 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 LRP2 MAP4K5 MARCHF5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 TSC1 USP7 ZC3H12A	16 interacting genes: ANTXR2 APP ATF7IP CENPU KEAP1 LAMA5 NID1 NID2 PSMC5 SMARCA2 SNAPIN SNX2 SRPK1 TANK UBC WASHC3
Entrez ID		10010	3915
HPRD ID		04870	01030
Ensembl ID		ENSG00000136560	ENSG00000135862
Uniprot IDs		B2R7S3 Q6NW12 Q92844	P11047 Q6NVY8
PDB IDs		1KZZ 1L0A 5H10	5XAU
Enriched GO Terms of Interacting Partners?
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