TANK and IKBKE

Number of citations of the paper that reports this interaction (PubMedID 17568778)
74

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		TANK	IKBKE
Description		TRAF family member associated NFKB activator	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Mitochondrial Membrane
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding	Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Proteolysis Cellular Response To DNA Damage Stimulus Signal Transduction I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Gene Expression Positive Regulation Of Lipid Storage Peptidyl-serine Phosphorylation Response To Type I Interferon Response To Interferon-beta NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly MRNA Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Type I Interferon-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Cellular Response To Virus
Pathways		TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs			Fostamatinib
Diseases
GWAS		Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966 33272962)
Interacting Genes		33 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 LRP2 MAP4K5 MARCHF5 PLK1 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 TSC1 USP7 ZC3H12A	26 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CSF2 CYLD DAXX DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP MUC1 NFKBIA PTGFR RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		10010	9641
HPRD ID		04870	05442
Ensembl ID		ENSG00000136560	ENSG00000263528
Uniprot IDs		B2R7S3 Q6NW12 Q92844	A0A075B7B4 Q14164
PDB IDs		1KZZ 1L0A 5H10
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?