TGM3 and HLCS

		TGM3	HLCS
Description		transglutaminase 3	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Extracellular Exosome	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Catalytic Activity Structural Molecule Activity Calcium Ion Binding Acyltransferase Activity	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Cellular Protein Modification Process Peptide Cross-linking Keratinocyte Differentiation Hair Follicle Morphogenesis Keratinization Cell Envelope Organization	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Monophosphate B-2-Octylglucoside Guanosine-5'-Diphosphate	Biotin
Diseases
GWAS		Basal cell carcinoma ( 31174203 33549134 24403052 25855136 27539887) Inflammatory skin disease ( 25574825) Keratinocyte cancer (MTAG) ( 31174203) Metabolite levels ( 23823483) Non-melanoma skin cancer ( 29739929)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		4 interacting genes: CALML5 HLCS HMGB1 UCHL5	17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1
Entrez ID		7053	3141
HPRD ID		02584	08360
Ensembl ID		ENSG00000125780	ENSG00000159267
Uniprot IDs		Q08188	P50747
PDB IDs		1L9M 1L9N 1NUD 1NUF 1NUG
Enriched GO Terms of Interacting Partners?
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