HLCS and SNX27

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		HLCS	SNX27
Description		holocarboxylase synthetase	sorting nexin 27
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Early Endosome Membrane
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Endocytic Recycling
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Body mass index ( 26426971)
Interacting Genes		17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1	10 interacting genes: ACE2 AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SUMO2
Entrez ID		3141	81609
HPRD ID		08360	11591
Ensembl ID		ENSG00000159267	ENSG00000143376
Uniprot IDs		P50747	A0A2R8Y8A7 Q96L92
PDB IDs			4HAS 5ZN9 6SAK
Enriched GO Terms of Interacting Partners?
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