HLCS and LANCL2

		HLCS	LANCL2
Description		holocarboxylase synthetase	LanC like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Nucleus Nucleoplasm Cytosol Plasma Membrane Cortical Actin Cytoskeleton
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Protein Binding ATP Binding GTP Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	Carbohydrate Metabolic Process Positive Regulation Of Abscisic Acid-activated Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		Biotin
Diseases
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Impulsivity ( 30718321) Mercury levels ( 26025379) Metabolite levels ( 23823483) QRS interval (sulfonylurea treatment interaction) ( 27958378) Spatial processing ( 31596458)
Interacting Genes		17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1	9 interacting genes: AKT1 APP APPBP2 HLCS RHOU SIAH1 TDRKH TERF2 TERF2IP
Entrez ID		3141	55915
HPRD ID		08360	13956
Ensembl ID		ENSG00000159267	ENSG00000132434
Uniprot IDs		P50747	B3KTN5 Q9NS86
PDB IDs
Enriched GO Terms of Interacting Partners?
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