HLCS and NGB

		HLCS	NGB
Description		holocarboxylase synthetase	neuroglobin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Mitochondrion Cytosol Perikaryon
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	Oxygen Carrier Activity Protein Binding Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	Apoptotic Process Oxygen Transport
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	Intracellular oxygen transport
Drugs		Biotin
Diseases
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1	22 interacting genes: AKT1 ATP1B2 BTBD2 C1orf94 DDIT4L FLOT1 GATAD2B GNAI1 GNAI2 GNAI3 GNAO1 HLCS IHO1 L3MBTL3 MEI4 NIF3L1 PTEN REL TDO2 TEPSIN VAC14 ZNF655
Entrez ID		3141	58157
HPRD ID		08360	05602
Ensembl ID		ENSG00000159267	ENSG00000165553
Uniprot IDs		P50747	A0M8W9 Q9NPG2
PDB IDs			1OJ6 4MPM
Enriched GO Terms of Interacting Partners?
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