HLCS and DDX52

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		HLCS	DDX52
Description		holocarboxylase synthetase	DExD-box helicase 52
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix	Nucleoplasm Nucleolus Membrane
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding	RNA Binding RNA Helicase Activity ATP Binding ATP Hydrolysis Activity
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	Maturation Of SSU-rRNA
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Biotin
Diseases
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)	Ovarian cancer ( 23535730)
Interacting Genes		17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1	5 interacting genes: AP4M1 HLCS MTNR1A PMP22 UTP23
Entrez ID		3141	11056
HPRD ID		08360	09911
Ensembl ID		ENSG00000159267	ENSG00000278053
Uniprot IDs		P50747	B3KM65 Q9Y2R4
PDB IDs			3DKP
Enriched GO Terms of Interacting Partners?
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