SMPD2 and NDRG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMPD2	NDRG4
Description		sphingomyelin phosphodiesterase 2	NDRG family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Basolateral Plasma Membrane Cell Projection Membrane
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process	Heart Looping Signal Transduction Brain Development Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Height ( 18391951)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Liver enzyme levels (alanine transaminase) ( 33972514) Oily fish consumption ( 32066663) Pork consumption ( 32066663) QT interval ( 22726844 19305408 19305409) Schizophrenia ( 29483656)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	41 interacting genes: ADCY9 AGTRAP ALDH6A1 APLNR ARFIP2 ARL6IP1 ATP5PF CACFD1 CDR1 CIDEB CMTM3 CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 DHX38 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 NOL3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A
Entrez ID		6610	65009
HPRD ID		04608	14817
Ensembl ID		ENSG00000135587	ENSG00000103034
Uniprot IDs		O60906	A0A024R6V8 A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0
PDB IDs
Enriched GO Terms of Interacting Partners?
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