SMPD2 and PITPNC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMPD2	PITPNC1
Description		sphingomyelin phosphodiesterase 2	phosphatidylinositol transfer protein cytoplasmic 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Protein Binding Phosphatidylcholine Transporter Activity Phosphatidylinositol Transfer Activity Phosphatidylinositol Binding Phosphatidic Acid Binding Phosphatidylglycerol Binding Phosphatidic Acid Transfer Activity
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process	Signal Transduction Phospholipid Transport Intermembrane Lipid Transfer
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Height ( 18391951)	Blood urea nitrogen levels ( 31152163 29403010) Body size at age 10 ( 32376654) Chronic central serous retinopathy ( 30073298) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Estimated glomerular filtration rate ( 31152163) Morning person ( 30696823) Plasma selenium concentration ( 33382417) Pulmonary function ( 23932459) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 32499647) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	14 interacting genes: AGTRAP ANKS6 CACFD1 CMTM5 DGAT2L6 GSG1 HTATIP2 KATNAL1 MAL2 REEP5 SCAMP5 SMPD2 SYP TNFRSF10D
Entrez ID		6610	26207
HPRD ID		04608	05504
Ensembl ID		ENSG00000135587	ENSG00000154217
Uniprot IDs		O60906	A0A0C4DGP0 Q9UKF7
PDB IDs
Enriched GO Terms of Interacting Partners?
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