SMPD2 and TMEM167B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMPD2	TMEM167B
Description		sphingomyelin phosphodiesterase 2	transmembrane protein 167B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Molecular_function Protein Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process	Constitutive Secretory Pathway
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Height ( 18391951)	Apolipoprotein B levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	33 interacting genes: ACKR2 AGPAT3 APOL3 AQP10 AQP6 ASPH C14orf180 CD300C CD47 CTXN3 EBP FXYD6-FXYD2 HSD17B11 HSD17B13 LETMD1 LSS MFSD14B MGST2 PLLP REEP4 SACM1L SEC22B SERINC2 SLC34A3 SMPD2 STX12 STX1B TAS2R19 TM4SF19 TMEM100 TMEM107 UNC50 ZDHHC21
Entrez ID		6610	56900
HPRD ID		04608	16474
Ensembl ID		ENSG00000135587	ENSG00000215717
Uniprot IDs		O60906	A0A024R096 A0A494C0V7 Q9NRX6
PDB IDs
Enriched GO Terms of Interacting Partners?
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