SMPD2 and ARFIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SMPD2	ARFIP1
Description		sphingomyelin phosphodiesterase 2	ADP ribosylation factor interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Membrane Cell Periphery	Golgi Membrane Cytosol Trans-Golgi Network Membrane
	Molecular Function	Phospholipase Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Metal Ion Binding	Protein Binding Phospholipid Binding Protein Domain Specific Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process	Intracellular Protein Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Protein Secretion Negative Regulation Of Retrograde Transport, Endosome To Golgi
Pathways		Glycosphingolipid metabolism Ceramide signalling TNFR1-mediated ceramide production
Drugs
Diseases
GWAS		Height ( 18391951)	Blood protein levels ( 29875488) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31	19 interacting genes: AFF1 ARF1 ARF3 ARF5 ARFIP2 BSND CMTM5 DESI2 KRT27 KRT33B MAGEA6 RPRM SCAMP1 SFT2D1 SLC2A4 SMIM5 SMPD2 SYNGR3 TNFRSF10D
Entrez ID		6610	27236
HPRD ID		04608	09331
Ensembl ID		ENSG00000135587	ENSG00000164144
Uniprot IDs		O60906	B4E273 B7ZA10 P53367 Q8N8M9
PDB IDs
Enriched GO Terms of Interacting Partners?
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