GAA and SH3GLB2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
5

Data Source:
BioGRID (two hybrid)

		GAA	SH3GLB2
Description		alpha glucosidase	SH3 domain containing GRB2 like, endophilin B2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Carbohydrate Binding Maltose Alpha-glucosidase Activity Alpha-glucosidase Activity	Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Glycogen Catabolic Process Sucrose Metabolic Process Glucose Metabolic Process Lysosome Organization Locomotory Behavior Tissue Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction
Pathways		Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Acarbose Miglitol AT2220
Diseases
GWAS		Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Blood metabolite levels ( 26401656) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		10 interacting genes: CPEB2 CREBBP DYNC1LI2 EP300 HIVEP1 NCF1 NUMBL PARD3B SH3GLB2 STAT2	38 interacting genes: CCDC158 CCND3 CDKN2D CNOT7 EFHC1 EXOSC1 EXOSC5 FHL3 FXR1 GAA GADD45G GIT2 GOLGA2 KDM1A KRTAP10-1 KRTAP10-8 KRTAP4-5 KRTAP5-11 KRTAP9-3 LGALS14 LNX2 LSM3 MAGEA1 MORF4L1 NMI NTAQ1 NXF1 OGT PICK1 SH3GLB1 SH3KBP1 SREK1 STX4 TBC1D7 TEX11 TRAF1 TSG101 YES1
Entrez ID		2548	56904
HPRD ID		06006	15334
Ensembl ID		ENSG00000171298	ENSG00000148341
Uniprot IDs		P10253	A0A024R896 B7ZC38 Q9NR46
PDB IDs		5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8
Enriched GO Terms of Interacting Partners?
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