GAA and DYNC1LI2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
5

Data Source:
BioGRID (two hybrid)

		GAA	DYNC1LI2
Description		alpha glucosidase	dynein cytoplasmic 1 light intermediate chain 2
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Kinetochore Lysosome Late Endosome Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Membrane
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Carbohydrate Binding Maltose Alpha-glucosidase Activity Alpha-glucosidase Activity	ATP Binding Identical Protein Binding Dynein Heavy Chain Binding
	Biological Process	Maltose Metabolic Process Regulation Of The Force Of Heart Contraction Diaphragm Contraction Heart Morphogenesis Glycogen Catabolic Process Sucrose Metabolic Process Glucose Metabolic Process Lysosome Organization Locomotory Behavior Tissue Development Vacuolar Sequestering Muscle Cell Cellular Homeostasis Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Cardiac Muscle Contraction	Microtubule Cytoskeleton Organization Microtubule-based Movement Centrosome Localization Cellular Response To Nerve Growth Factor Stimulus
Pathways		Glycogen storage disease type II (GAA) Neutrophil degranulation Glycogen breakdown (glycogenolysis)	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs		Acarbose Miglitol AT2220
Diseases
GWAS		Blood protein levels ( 30072576) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Lipid traits ( 30576415)
Interacting Genes		10 interacting genes: CPEB2 CREBBP DYNC1LI2 EP300 HIVEP1 NCF1 NUMBL PARD3B SH3GLB2 STAT2	9 interacting genes: APP BRCA2 CTRL DMTN FCSK GAA HPR OGT ZFHX3
Entrez ID		2548	1783
HPRD ID		06006	09923
Ensembl ID		ENSG00000171298	ENSG00000135720
Uniprot IDs		P10253	A0A024R6Z0 O43237 Q63HJ8
PDB IDs		5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8	6F1T 6F1Y 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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