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MAP2K4 and ITCH
Number of citations of the paper that reports this interaction (PubMedID
19737936
)
7
Data Source:
BioGRID
(enzymatic study)
MAP2K4
ITCH
Description
mitogen-activated protein kinase kinase 4
itchy E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Axon
Dendrite Cytoplasm
Perikaryon
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protein Kinase Activity
MAP Kinase Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
JUN Kinase Kinase Activity
Mitogen-activated Protein Kinase Kinase Kinase Binding
Protein Serine Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
Biological Process
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Apoptotic Process
Signal Transduction
JNK Cascade
Response To Wounding
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of DNA Replication
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Cell Growth Involved In Cardiac Muscle Cell Development
Cellular Response To Mechanical Stimulus
Cellular Response To Sorbitol
Cellular Senescence
Negative Regulation Of Motor Neuron Apoptotic Process
Protein Polyubiquitination
Regulation Of Cell Growth
Positive Regulation Of T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Alpha-beta T Cell Proliferation
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Receptor Catabolic Process
Pathways
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Uptake and function of anthrax toxins
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asthma (
32296059
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estimated glomerular filtration rate (
31152163
)
Response to amphetamines (
22952603
)
Serum alkaline phosphatase levels (
33339817
)
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31152163
31015462
)
Fish- and plant-related diet (
32066663
)
Heel bone mineral density (
28869591
)
Hip circumference adjusted for BMI (
34021172
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Vitiligo (
27723757
)
Interacting Genes
44 interacting genes:
AKT1
ALDOB
APP
ARRB1
ARRB2
CFLAR
CYLC2
DUSP22
EFNA4
FBP2
FLNA
FLNC
GEMIN5
ITCH
JUN
LRRK2
MAP2K6
MAP3K1
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAP3K7
MAP3K8
MAP4K2
MAPK1
MAPK10
MAPK12
MAPK14
MAPK7
MAPK8
MAPK8IP3
MAPK9
NBR1
RBBP8
SPAG9
STX17
TRIB1
UBC
108 interacting genes:
AGO2
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CEP250
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
ERBB4
EWSR1
FYN
GLIS3
GNAI2
HNRNPL
HNRNPUL1
JUN
JUNB
KPNB1
KSR1
LAPTM5
LITAF
LRRK1
MAP2K1
MAP2K4
MAPK8
MLANA
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NRAS
NUDT21
NUMB
PABPC1
PACSIN1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
PRRG4
RAF1
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
STAM2
SUFU
TAB1
TP63
TP73
TRPC4
TRPV1
TRPV4
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
WASL
WBP2
YWHAQ
Entrez ID
6416
83737
HPRD ID
03213
07565
Ensembl ID
ENSG00000065559
ENSG00000078747
Uniprot IDs
P45985
A0A590UJQ1
Q96J02
PDB IDs
3ALN
3ALO
3VUT
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
Enriched GO Terms of Interacting Partners
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