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ITCH and POLR2B
Number of citations of the paper that reports this interaction (PubMedID
16055720
)
92
Data Source:
BioGRID
(pull down)
ITCH
POLR2B
Description
itchy E3 ubiquitin protein ligase
RNA polymerase II subunit B
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
RNA Polymerase II Activity
DNA Binding
Chromatin Binding
RNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Ribonucleoside Binding
Metal Ion Binding
Biological Process
Protein Polyubiquitination
Regulation Of Cell Growth
Positive Regulation Of T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Negative Regulation Of Alpha-beta T Cell Proliferation
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Receptor Catabolic Process
Transcription By RNA Polymerase II
Pathways
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31152163
31015462
)
Fish- and plant-related diet (
32066663
)
Heel bone mineral density (
28869591
)
Hip circumference adjusted for BMI (
34021172
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Vitiligo (
27723757
)
Age-related macular degeneration (
21909106
)
Bitter alcoholic beverage consumption (
31046077
)
Congenital heart disease (maternal effect) (
28468790
)
Coronary artery disease (
29212778
)
Height (
20881960
25429064
)
Metabolite levels (
23823483
)
White blood cell count (
29403010
)
Interacting Genes
108 interacting genes:
AGO2
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CEP250
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
ERBB4
EWSR1
FYN
GLIS3
GNAI2
HNRNPL
HNRNPUL1
JUN
JUNB
KPNB1
KSR1
LAPTM5
LITAF
LRRK1
MAP2K1
MAP2K4
MAPK8
MLANA
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NRAS
NUDT21
NUMB
PABPC1
PACSIN1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
PRRG4
RAF1
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
STAM2
SUFU
TAB1
TP63
TP73
TRPC4
TRPV1
TRPV4
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
WASL
WBP2
YWHAQ
19 interacting genes:
BTF3
CALM1
CCNH
CDK7
CTDP1
IKBKG
ITCH
LZTR1
MEN1
NEDD4
OTUD5
POLR2C
POLR2D
POLR2H
POLR2L
PTEN
SNAR-B2
SUB1
ZSCAN1
Entrez ID
83737
5431
HPRD ID
07565
15943
Ensembl ID
ENSG00000078747
ENSG00000047315
Uniprot IDs
A0A590UJQ1
Q96J02
B4DH29
B4DHJ3
C9J2Y9
P30876
PDB IDs
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
Enriched GO Terms of Interacting Partners
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