MAP2K4 and DUSP22

Number of citations of the paper that reports this interaction (PubMedID 11346645)
13

Data Source:
HPRD (in vitro, in vivo)

		MAP2K4	DUSP22
Description		mitogen-activated protein kinase kinase 4	dual specificity phosphatase 22
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GO Annotations	Cellular Component	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon	Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium
	Molecular Function	Protein Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine Kinase Activity	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Signal Transduction JNK Cascade Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Motor Neuron Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Regulation Of Cell Population Proliferation Positive Regulation Of JNK Cascade Negative Regulation Of Focal Adhesion Assembly Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Pathways		Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603) Serum alkaline phosphatase levels ( 33339817)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Albumin-globulin ratio ( 29403010) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Crohn's disease ( 26192919) Eosinophil counts ( 32888494) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 28196072) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010) Systemic lupus erythematosus ( 33536424) Takayasu arteritis ( 30498034)
Interacting Genes		44 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK7 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC	5 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8
Entrez ID		6416	56940
HPRD ID		03213	13255
Ensembl ID		ENSG00000065559	ENSG00000112679
Uniprot IDs		P45985	A0A384NLC8 Q9NRW4
PDB IDs		3ALN 3ALO 3VUT	1WRM 4WOH 6L1S 6LMY 6LOT 6LOU 6LVQ 7C8S
Enriched GO Terms of Interacting Partners?
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