PLEKHB1 and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PLEKHB1	RAP1GDS1
Description		pleckstrin homology domain containing B1	Rap1 GTPase-GDP dissociation stimulator 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Integral Component Of Membrane	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	Phototransduction Regulation Of Cell Differentiation	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration
Pathways			RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Dimensional psychopathology (Cognitive) ( 29496196) Glucose homeostasis traits ( 25524916) Hand grip strength ( 27325353) Smoking status (ever vs never smokers) ( 30643258)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		13 interacting genes: ACVR1 ATXN1 BAG3 BMPR1B C10orf55 CCR8 GLIS2 GNGT1 RAP1GDS1 SMAD1 TGFBR1 VENTX ZDHHC17	28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451
Entrez ID		58473	5910
HPRD ID		09630	11763
Ensembl ID		ENSG00000021300	ENSG00000138698
Uniprot IDs		A0A024R5H7 A0A024R5H9 A0A024R5J2 Q9UF11	B3KNU0 P52306 Q6U7G8
PDB IDs			5XGC 5ZHX
Enriched GO Terms of Interacting Partners?
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