RAP1GDS1 and RRAS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAP1GDS1	RRAS
Description		Rap1 GTPase-GDP dissociation stimulator 1	RAS related
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Plasma Membrane Focal Adhesion Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle	SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	18 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RAP1GDS1 RASIP1 RASSF5 SOS1 TRIM55 TRIM63
Entrez ID		5910	6237
HPRD ID		11763	01299
Ensembl ID		ENSG00000138698	ENSG00000126458
Uniprot IDs		B3KNU0 P52306 Q6U7G8	A0A024QZF2 P10301
PDB IDs		5XGC 5ZHX	2FN4
Enriched GO Terms of Interacting Partners?
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