RAP1GDS1 and ANTXR2

		RAP1GDS1	ANTXR2
Description		Rap1 GTPase-GDP dissociation stimulator 1	ANTXR cell adhesion molecule 2
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Integral Component Of Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Metal Ion Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Toxin Transport
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs			MDX-1303
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Adult body size ( 32376654) Ankylosing spondylitis ( 21743469 20062062) Bipolar disorder (inflammation and infection response interaction) ( 25781172) Carotid plaque burden ( 28282560) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Essential hypertension (time to event) ( 32589924) Hand grip strength ( 29691431) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Myopia ( 27182965) Neutrophil percentage of white cells ( 32888494 27863252) Refractive error ( 32231278) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Spherical equivalent or myopia (age of diagnosis) ( 29808027) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	11 interacting genes: COL4A2 COL4A3 COL4A4 COL4A5 DDX10 FRAS1 LAMB1 LAMC1 LRP6 RAP1GDS1 SMAD2
Entrez ID		5910	118429
HPRD ID		11763	07452
Ensembl ID		ENSG00000138698	ENSG00000163297
Uniprot IDs		B3KNU0 P52306 Q6U7G8	A4FUA5 J3KPY9 P58335 Q32Q26
PDB IDs		5XGC 5ZHX	1SHT 1SHU 1T6B 1TZN
Enriched GO Terms of Interacting Partners?
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