RAP1GDS1 and RAP2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RAP1GDS1	RAP2B
Description		Rap1 GTPase-GDP dissociation stimulator 1	RAP2B, member of RAS oncogene family
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GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	GTPase Activator Activity Protein Binding	GTPase Activity G Protein Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding
	Biological Process	Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of GTPase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier
Pathways		RHOT2 GTPase cycle RHOT1 GTPase cycle	Neutrophil degranulation
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)	Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)
Interacting Genes		28 interacting genes: ABCB7 ANTXR2 CDC42 DIRAS1 DIRAS2 DOC2A EGFR HRAS KIFAP3 KRAS LEF1 MBIP MED28 NRAS OGT PLEKHB1 PTPRF PUF60 RAB6B RAC1 RAP1A RAP2B RAP2C RHOA RNF19B RRAS RRAS2 ZNF451	10 interacting genes: CAMK2B PDE6D PRKAR2B RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A
Entrez ID		5910	5912
HPRD ID		11763	01548
Ensembl ID		ENSG00000138698	ENSG00000181467
Uniprot IDs		B3KNU0 P52306 Q6U7G8	P61225
PDB IDs		5XGC 5ZHX	1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?
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