BACH1 and HLCS

		BACH1	HLCS
Description		BTB domain and CNC homolog 1	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Heme Binding	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation
Pathways		Regulation of HMOX1 expression and activity Heme signaling Regulation of BACH1 activity	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs			Biotin
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Aspartate aminotransferase levels ( 33547301) Creatine kinase levels ( 29403010) Haemorrhoidal disease ( 33888516) Pancreatic cancer ( 22158540) Selective IgA deficiency ( 27723758) Visceral fat ( 22589738)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		10 interacting genes: ANAPC5 ATF2 DDIT3 HLCS HMMR MAFB MAFK PATZ1 RBCK1 TCF4	17 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 SNX27 SOD1 SPATA46 TGM3 WIPF1
Entrez ID		571	3141
HPRD ID		04127	08360
Ensembl ID		ENSG00000156273	ENSG00000159267
Uniprot IDs		O14867	P50747
PDB IDs		2IHC
Enriched GO Terms of Interacting Partners?
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