CASS4 and CDC42EP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CASS4	CDC42EP2
Description		Cas scaffold protein family member 4	CDC42 effector protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Microtubule Cytoskeleton Membrane Phagocytic Vesicle
	Molecular Function	Protein Tyrosine Kinase Binding	Opioid Peptide Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Actin Filament Organization Rho Protein Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Catalytic Activity Cellular Response To Interferon-gamma
Pathways			MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Cognitive decline (age-related) ( 28078323) Family history of Alzheimer's disease ( 30617256) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive astigmatism ( 25367360)	Acne (severe) ( 24927181) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252)
Interacting Genes		6 interacting genes: ANKS1B CDC42EP2 FHL3 HSF2BP RAE1 ZYX	11 interacting genes: ARHGAP26 CASS4 CDC42 COX5B NEDD9 NME7 PICK1 RHOQ SEPTIN6 SEPTIN7 SNCA
Entrez ID		57091	10435
HPRD ID		09842	09363
Ensembl ID		ENSG00000087589	ENSG00000149798
Uniprot IDs		B4DII4 Q9NQ75	O14613
PDB IDs		2CRE
Enriched GO Terms of Interacting Partners?
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