CDC42EP2 and CASS4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CDC42EP2	CASS4
Description		CDC42 effector protein 2	Cas scaffold protein family member 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Microtubule Cytoskeleton Membrane Phagocytic Vesicle	Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion
	Molecular Function	Opioid Peptide Activity GTPase Activator Activity Protein Binding Small GTPase Binding	Protein Tyrosine Kinase Binding
	Biological Process	Actin Filament Organization Rho Protein Signal Transduction Regulation Of Cell Shape Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Protein-containing Complex Assembly Regulation Of Catalytic Activity Cellular Response To Interferon-gamma	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		MAPK6/MAPK4 signaling CDC42 GTPase cycle RHOQ GTPase cycle
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252)	Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Cognitive decline (age-related) ( 28078323) Family history of Alzheimer's disease ( 30617256) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Refractive astigmatism ( 25367360)
Interacting Genes		11 interacting genes: ARHGAP26 CASS4 CDC42 COX5B NEDD9 NME7 PICK1 RHOQ SEPTIN6 SEPTIN7 SNCA	6 interacting genes: ANKS1B CDC42EP2 FHL3 HSF2BP RAE1 ZYX
Entrez ID		10435	57091
HPRD ID		09363	09842
Ensembl ID		ENSG00000149798	ENSG00000087589
Uniprot IDs		O14613	B4DII4 Q9NQ75
PDB IDs			2CRE
Enriched GO Terms of Interacting Partners?
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