SLF2 and SMC5

Number of citations of the paper that reports this interaction (PubMedID 32389690)
5

Data Source:
BioGRID (two hybrid, pull down)

		SLF2	SMC5
Description		SMC5-SMC6 complex localization factor 2	structural maintenance of chromosomes 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Site Of Double-strand Break Intracellular Membrane-bounded Organelle	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Cytoplasm PML Body Nuclear Speck Cell Junction Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Protein Binding ATP Binding
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Sister Chromatid Cohesion Internal Peptidyl-lysine Acetylation Stem Cell Population Maintenance Chromosome Condensation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Phase Transition Cell Division Positive Regulation Of Chromosome Segregation Protein Localization To Chromosome, Centromeric Region Cellular Senescence
Pathways			SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)	Age at first sexual intercourse ( 27089180)
Interacting Genes		8 interacting genes: CALM1 OPTN PSMA1 SFMBT2 SLF1 SMC5 SMC6 TRIM14	6 interacting genes: DISC1 EID3 NSMCE2 SLF2 SMN1 TK1
Entrez ID		55719	23137
HPRD ID		12581	10241
Ensembl ID		ENSG00000119906	ENSG00000198887
Uniprot IDs		Q8IX21	Q8IY18
PDB IDs
Enriched GO Terms of Interacting Partners?
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