SLF2 and SMC6

Number of citations of the paper that reports this interaction (PubMedID 32389690)
5

Data Source:
BioGRID (pull down, pull down)

		SLF2	SMC6
Description		SMC5-SMC6 complex localization factor 2	structural maintenance of chromosomes 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Site Of Double-strand Break Intracellular Membrane-bounded Organelle	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm PML Body Nuclear Speck Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break Mitotic Spindle Pole
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding Ubiquitin Protein Ligase Binding
	Biological Process	DNA Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Cellular Response To DNA Damage Stimulus Positive Regulation Of Chromosome Segregation Cellular Senescence
Pathways			SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung cancer ( 28604730)	LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Total cholesterol levels ( 30275531)
Interacting Genes		8 interacting genes: CALM1 OPTN PSMA1 SFMBT2 SLF1 SMC5 SMC6 TRIM14	1 interacting genes: SLF2
Entrez ID		55719	79677
HPRD ID		12581	10242
Ensembl ID		ENSG00000119906	ENSG00000163029
Uniprot IDs		Q8IX21	A0A2S1ZR87 Q96SB8
PDB IDs
Enriched GO Terms of Interacting Partners?
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