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POLE3 and POLE4
Number of citations of the paper that reports this interaction (PubMedID
10801849
)
28
Data Source:
HPRD
(in vitro)
POLE3
POLE4
Description
DNA polymerase epsilon 3, accessory subunit
DNA polymerase epsilon 4, accessory subunit
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Epsilon DNA Polymerase Complex
CHRAC
Nucleus
Nucleoplasm
Epsilon DNA Polymerase Complex
Molecular Function
DNA-directed DNA Polymerase Activity
Protein Binding
Chromatin DNA Binding
Protein Heterodimerization Activity
DNA Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Protein Heterodimerization Activity
Biological Process
DNA Replication
Leading Strand Elongation
Cellular Response To DNA Damage Stimulus
Heterochromatin Assembly
Nucleosome Mobilization
Histone H3 Acetylation
DNA Biosynthetic Process
DNA Biosynthetic Process
Pathways
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Drugs
Cladribine
Cladribine
Diseases
GWAS
Venous thromboembolism (
33592630
)
Interacting Genes
14 interacting genes:
ALAD
APP
ASTN2
BAZ1A
CHRAC1
CST3
DR1
DRAP1
EIF4G2
GSN
POLE4
SMARCA5
TNC
TRIM32
11 interacting genes:
B4GALT4
EVA1A
HSPA13
NFYB
POLE
POLE2
POLE3
PRKAR1B
REG3G
SGO1
UBE3A
Entrez ID
54107
56655
HPRD ID
06274
16238
Ensembl ID
ENSG00000148229
ENSG00000115350
Uniprot IDs
A0A024R829
Q9NRF9
Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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