POLE3 and EIF4G2

		POLE3	EIF4G2
Description		DNA polymerase epsilon 3, accessory subunit	eukaryotic translation initiation factor 4 gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex CHRAC	Cytosol Adherens Junction Membrane Eukaryotic Translation Initiation Factor 4F Complex Axon
	Molecular Function	DNA-directed DNA Polymerase Activity Protein Binding Chromatin DNA Binding Protein Heterodimerization Activity	RNA Binding MRNA Binding Translation Initiation Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	DNA Replication Leading Strand Elongation Cellular Response To DNA Damage Stimulus Heterochromatin Assembly Nucleosome Mobilization Histone H3 Acetylation DNA Biosynthetic Process	Translational Initiation Regulation Of Translational Initiation Heart Development Cell Death Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Cellular Macromolecule Biosynthetic Process Positive Regulation Of Translation Positive Regulation Of Axon Extension Regulation Of Cell Cycle Positive Regulation Of Dendritic Spine Development
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	ISG15 antiviral mechanism
Drugs		Cladribine
Diseases
GWAS			Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: ALAD APP ASTN2 BAZ1A CHRAC1 CST3 DR1 DRAP1 EIF4G2 GSN POLE4 SMARCA5 TNC TRIM32	16 interacting genes: C1QTNF9 CASP3 CREBBP EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 OGT POLE3 RPA2 SKIL SUMO2
Entrez ID		54107	1982
HPRD ID		06274	09084
Ensembl ID		ENSG00000148229	ENSG00000110321
Uniprot IDs		A0A024R829 Q9NRF9	P78344 Q2TU89
PDB IDs			3D3M 3L6A 4IUL
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?